our study indicates that the immunosuppressive cytokine milieu rich in IL-10 and TNFα in HPV-negative but not in
HPV-positive HNSCC significantly affects the functional capacity of tumor-infiltrating pDCs, and such dysfunctional
pDCs may further support the immunosuppressive tumor microenvironment by promoting the expansion of Tregs
in the tumor tissue.
Cancer Immunol Immunother. 2021 Feb 11.
YVMA insertion is associated with a higher incidence of brain metastasis, and inferior outcomes to chemotherapy
than non-YVMA variants in patients with advanced NSCLC and HER2 kinase domain mutations, which emphasized
the unmet need of more potent anti-cancer therapies with high blood-brain barrier (BBB) penetration capacity for
patients with YVMA insertion.
Transl Lung Cancer Res. 2021 Feb;10(2):753-765.
CfDNA and cfRNA derived from pleural effusion supernatant have been successfully tested with a PCR-based
multigene detection kit. Pleural effusion supernatant seems a preferred material for detection of multigene
alterations to guide treatment decision of advanced NSCLC.
Cancer Med. 2021 Apr;10(7):2286-2292.
It was feasible to test EGFR mutation in cerebrospinal fluid and plasma. In LADC patients with brain metastasis,
cerebrospinal fluid can be used as a liquid biopsy specimen to guide treatment strategy by monitoring EGFR
Front. Oncol., 22 March 2021
Regardless of the device used, a tissue surface area of ≥ 1 mm2 is adequate for samples to be tested with NGS.
Diagnostics (Basel). 2021 Feb 25;11(3):391.
Patients with NSCLC in Qujing displayed a unique profile of driver gene mutations, especially a higher prevalence of
EGFR compound mutations and dominant KRAS G12C subtype, in this study, indicating a peculiar etiology of NSCLC
in Qujing. Therefore, a different paradigm of therapeutic strategy might need to be considered for patients with
NSCLC in Qujing.
Front. Oncol., 13 April 2021